80/20 Principle: Application in Manufacturing Companies

Responding to the request of a company in pushing the income statement in profit, the authors of this article propose to apply to the products contribution margin the 80/20 principl

Perceived control and hedonic tone dynamics during performance in elite shooters

Purpose: The purpose of the study was to investigate the individuals' dynamics of perceived control and hedonic tone over time, with respect to the 4 performance states as conceptualized within the multiaction plan (MAP) model. We expected to find idiosyncratic and differentiated trends over time in the scores of perceived control and hedonic tone, typified by fluctuations among 2 optimal and 2 suboptimal types of processing during performance. Method: Ten elite-level shooters participated in the study. They were asked to identify the most relevant, idiosyncratic core component of their shooting action and perform 120 shots distanced 10 m from the target. Subjective accounts of perceived control and hedonic tone of the core component of action were assessed prior to and after each shot. We used a probabilistic approach to derive the 4 performance categories according to 2 × 2 interactions of perceived control and performance and hedonic tone and performance. Results: Logistic ordinal regression analysis enabled the identification of 4 idiosyncratic performance types for each athlete with respect to perceived control and hedonic tone intensity scores. Within- and between-individual differences in intensity bandwidth and probability levels were apparent across the 4 performance types. Changes among 4 types of processing were also observed during performance. Conclusion: Consistent with the MAP model conceptualization, the findings provided support for the different patterns of perceived control and hedonic tone intensity scores during performance. The results suggest applied arguments for using action- and emotion-centered strategies to help athletes in reaching and sustaining optimal performance states

Performance of prototypes for the ALICE electromagnetic calorimeter

The performance of prototypes for the ALICE electromagnetic sampling calorimeter has been studied in test beam measurements at FNAL and CERN. A $4\times4$ array of final design modules showed an energy resolution of about 11% /$\sqrt{E(\mathrm{GeV})}$ $\oplus$ 1.7 % with a uniformity of the response to electrons of 1% and a good linearity in the energy range from 10 to 100 GeV. The electromagnetic shower position resolution was found to be described by 1.5 mm $\oplus$ 5.3 mm /$\sqrt{E \mathrm{(GeV)}}$. For an electron identification efficiency of 90% a hadron rejection factor of $>600$ was obtained.Comment: 10 pages, 10 figure

Estudio experimental del campo de velocidades del viento en torno al modelo reducido de una vivienda

Este trabajo trata del relevamiento experimental del campo de velocidades del escurrimiento alrededor de una vivienda, baja, aislada y cerrada. El análisis se realiza utilizando un túnel de viento de pequeñas dimensiones sobre un modelo reducido construido con una escala 1/40 con relación a la vivienda. Se utilizó un flujo turbulento con distribución uniforme de velocidades medias del orden de los 16 m/s en la zona de ensayo. Los resultados obtenidos permiten caracterizar el campo de velocidades y la turbulencia para condiciones estacionarias, permitiendo identificar zonas con fenómenos aerodinámicos característicos que se generan en las inmediaciones de este tipo de estructuras (bajas y con aristas vivas). De esta manera se realizó la caracterización en diversos sectores, cercanos al recinto, de la componente longitudinal de altas frecuencias de las fluctuaciones de velocidad del escurrimiento medio (espectro micrometeorológico), pero debe advertirse que estos resultados no consideran las variaciones de las componentes de baja frecuencia (medias horarias, etc.).This work is about the experimental measurement of the velocities field of the flow surrounding an isolated, cladding low-rise house. The analysis is performed on a reduced model built in a scale of 1/40 in regard with the house using a small wind tunnel. A turbulent flow with uniform mean velocity distribution, which was in an order of 16 m/s, was used in the test section. The obtained results allow characterizing the velocities field and the turbulence for stationary conditions, allowing the identification of areas with characteristic aerodynamic phenomena that are generated in the neighbourhood of this kind of structures (low-rise building with sharp edges). Therefore, it was characterized in each area the high frequency component of the velocity fluctuations (micrometeorology spectrum), though it must be noted that these results do not consider the low frequency variations (hourly means, etc.).Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Estudio experimental del campo de velocidades del viento en torno al modelo reducido de una vivienda

Este trabajo trata del relevamiento experimental del campo de velocidades del escurrimiento alrededor de una vivienda, baja, aislada y cerrada. El análisis se realiza utilizando un túnel de viento de pequeñas dimensiones sobre un modelo reducido construido con una escala 1/40 con relación a la vivienda. Se utilizó un flujo turbulento con distribución uniforme de velocidades medias del orden de los 16 m/s en la zona de ensayo. Los resultados obtenidos permiten caracterizar el campo de velocidades y la turbulencia para condiciones estacionarias, permitiendo identificar zonas con fenómenos aerodinámicos característicos que se generan en las inmediaciones de este tipo de estructuras (bajas y con aristas vivas). De esta manera se realizó la caracterización en diversos sectores, cercanos al recinto, de la componente longitudinal de altas frecuencias de las fluctuaciones de velocidad del escurrimiento medio (espectro micrometeorológico), pero debe advertirse que estos resultados no consideran las variaciones de las componentes de baja frecuencia (medias horarias, etc.).This work is about the experimental measurement of the velocities field of the flow surrounding an isolated, cladding low-rise house. The analysis is performed on a reduced model built in a scale of 1/40 in regard with the house using a small wind tunnel. A turbulent flow with uniform mean velocity distribution, which was in an order of 16 m/s, was used in the test section. The obtained results allow characterizing the velocities field and the turbulence for stationary conditions, allowing the identification of areas with characteristic aerodynamic phenomena that are generated in the neighbourhood of this kind of structures (low-rise building with sharp edges). Therefore, it was characterized in each area the high frequency component of the velocity fluctuations (micrometeorology spectrum), though it must be noted that these results do not consider the low frequency variations (hourly means, etc.).Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Estudio experimental del campo de velocidades del viento en torno al modelo reducido de una vivienda

Este trabajo trata del relevamiento experimental del campo de velocidades del escurrimiento alrededor de una vivienda, baja, aislada y cerrada. El análisis se realiza utilizando un túnel de viento de pequeñas dimensiones sobre un modelo reducido construido con una escala 1/40 con relación a la vivienda. Se utilizó un flujo turbulento con distribución uniforme de velocidades medias del orden de los 16 m/s en la zona de ensayo. Los resultados obtenidos permiten caracterizar el campo de velocidades y la turbulencia para condiciones estacionarias, permitiendo identificar zonas con fenómenos aerodinámicos característicos que se generan en las inmediaciones de este tipo de estructuras (bajas y con aristas vivas). De esta manera se realizó la caracterización en diversos sectores, cercanos al recinto, de la componente longitudinal de altas frecuencias de las fluctuaciones de velocidad del escurrimiento medio (espectro micrometeorológico), pero debe advertirse que estos resultados no consideran las variaciones de las componentes de baja frecuencia (medias horarias, etc.).This work is about the experimental measurement of the velocities field of the flow surrounding an isolated, cladding low-rise house. The analysis is performed on a reduced model built in a scale of 1/40 in regard with the house using a small wind tunnel. A turbulent flow with uniform mean velocity distribution, which was in an order of 16 m/s, was used in the test section. The obtained results allow characterizing the velocities field and the turbulence for stationary conditions, allowing the identification of areas with characteristic aerodynamic phenomena that are generated in the neighbourhood of this kind of structures (low-rise building with sharp edges). Therefore, it was characterized in each area the high frequency component of the velocity fluctuations (micrometeorology spectrum), though it must be noted that these results do not consider the low frequency variations (hourly means, etc.).Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

Medulloblastoma is the most common malignant brain tumor of childhood. Despite numerous advances, clinical challenges range from recurrent and progressive disease to long-term toxicities in survivors. The lack of more effective, less toxic therapies results from our limited understanding of medulloblastoma growth. Although TP53 is the most commonly altered gene in cancers, it is rarely mutated in medulloblastoma. Accumulating evidence, however, indicates that TP53 pathways are disrupted in medulloblastoma. Wild-typep53-induced phosphatase 1 (WIP1 or PPM1D) encodes a negative regulator of p53. WIP1 amplification (17q22-q23) and its overexpression have been reported in diverse cancer types. We examined primary medulloblastoma specimens and cell lines, and detected WIP1 copy gain and amplification prevalent among but not exclusively in the tumors with 17q gain and isochromosome 17q (i17q), which are among the most common cytogenetic lesions in medulloblastoma. WIP1 RNA levels were significantly higher in the tumors with 17q gain or i17q. Immunoblots confirmed significant WIP1 protein in primary tumors, generally higher in those with 17q gain or i17q. Under basal growth conditions and in response to the chemotherapeutic agent, etoposide, WIP1 antagonized p53-mediated apoptosis in medulloblastoma cell lines. These results indicate that medulloblastoma express significant levels of WIP1 that modulate genotoxic responsiveness by negatively regulating p53

Comprehensive evaluation of methods to assess overall and cell-specific immune infiltrates in breast cancer

Background: Breast cancer (BC) immune infiltrates play a critical role in tumor progression and response to treatment. Besides stromal tumor infiltrating lymphocytes (sTILs) which have recently reached level 1B evidence as a prognostic marker in triple negative BC, a plethora of methods to assess immune infiltration exists, and it is unclear how these compare to each other and if they can be used interchangeably. Methods: Two experienced pathologists scored sTIL, intra-tumoral TIL (itTIL), and 6 immune cell types (CD3+, CD4+, CD8+, CD20+, CD68+, FOXP3+) in the International Cancer Genomics Consortium breast cancer cohort using hematoxylin and eosin-stained (n = 243) and immunohistochemistry-stained tissue microarrays (n = 254) and whole slides (n = 82). The same traits were evaluated using transcriptomic- and methylomic-based deconvolution methods or signatures. Results: The concordance correlation coefficient (CCC) between pathologists for sTIL was very good (0.84) and for cell-specific immune infiltrates slightly lower (0.63-0.66). Comparison between tissue microarray and whole slide pathology scores revealed systematically higher values in whole slides (ratio 2.60-5.98). The Spearman correlations between microscopic sTIL and transcriptomic- or methylomic-based assessment of immune infilt

Ground/space, passive/active remote sensing observations coupled with particle dispersion modelling to understand the inter-continental transport of wildfire smoke plumes

During the 2017 record-breaking burning season in Canada/United States, intense wild fires raged during the first week of September in the Pacific northwestern region (British Columbia, Alberta, Washington, Oregon, Idaho, Montana and northern California) burning mostly temperate coniferous forests. The heavy loads of smoke particles emitted in the atmosphere reached the Iberian Peninsula (IP) a few days later on 7 and 8 September. Satellite imagery allows to identify two main smoke clouds emitted during two different periods that were injected and transported in the atmosphere at several altitude levels. Columnar properties on 7 and 8 September at two Aerosol Robotic Network (AERONET) mid-altitude, background sites in northern and southern Spain are: aerosol optical depth (AOD) at 440 nm up to 0.62, Ångström exponent of 1.6–1.7, large dominance of small particles (fine mode fraction >0.88), low absorption AOD at 440 nm (0.98). Profiles from the Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) show the presence of smoke particles in the stratosphere during the transport, whereas the smoke is only observed in the troposphere at its arrival over the IP. Portuguese and Spanish ground lidar stations from the European Aerosol Research Lidar Network/Aerosols, Clouds, and Trace gases Research InfraStructure Network (EARLINET/ACTRIS) and the Micro-Pulse Lidar NETwork (MPLNET) reveal smoke plumes with different properties: particle depolarization ratio and color ratio, respectively, of 0.05 and 2.5 in the mid troposphere (5–9 km) and of 0.10 and 3.0 in the upper troposphere (10–13 km). In the mid troposphere the particle depolarization ratio does not seem time-dependent during the transport whereas the color ratio seems to increase (larger particles sediment first). To analyze the horizontal and vertical transport of the smoke from its origin to the IP, particle dispersion modelling is performed with the Hybrid Single Particle Lagrangian Integrated Trajectory Model (HYSPLIT) parameterized with satellite-derived biomass burning emission estimates from the Global Fire Assimilation System (GFAS) of the Copernicus Atmosphere Monitoring Service (CAMS). Three compounds are simulated: carbon monoxide, black carbon and organic carbon. The results show that the first smoke plume which travels slowly reaches rapidly (~1 day) the upper troposphere and lower stratosphere (UTLS) but also shows evidence of large scale horizontal dispersion, while the second plume, entrained by strong subtropical jets, reaches the upper troposphere much slower (~2.5 days). Observations and dispersion modelling all together suggest that particle depolarization properties are enhanced during their vertical transport from the mid to the upper troposphere.Spanish groups acknowledge the Spanish Ministry of Economy and Competitivity (MINECO) (ref. CGL2013-45410-R, CGL2014-52877-R, CGL2014-55230-R, TEC2015-63832-P, CGL2015-73250-JIN, CGL2016-81092-R and CGL2017-85344-R)European Union through H2020 programme ACTRIS-2, grant 654109European Union through H2020 programme EUNADICS-AV, grant 723986European Union through H2020 programme GRASP-ACE, grant 77834